The neurobiology of psychedelic sensation, feeling, and behavior
About Sophie
Sophie is a post-doctoral fellow at the University of Pennsylvania studying the effect of psilocybin on predictive processing and cognitive flexibility in mouse models of Autism Spectrum Disorder. Sophie completed her Ph.D., “Effect of psilocybin on persistent aversive signaling across the cingulate cortex,” in Gregory Corder’s lab at the University of Pennsylvania in 2025, where she was an NRSA F31 fellow. Over the course of her Ph.D., Sophie discovered how psilocybin modulates retrosplenial and anterior cingulate cortex dynamics to aid recovery in mouse models of PTSD and chronic pain, resulting in multiple high impact publications. Sophie graduated magna cum laude from the University of Chicago in 2020 with a B.S. in Neuroscience and a minor in Philosophy.
In the future, Sophie intends to run a translational research laboratory using high-throughput neurophysiological recording techniques and cell-type specific optogenetics to dissect the convergent and divergent mechanisms of psychedelics’ profound transdiagnostic impact.
Featured projects
Oswell, C.S., Rogers, S.A., James, J.G. et al. Mimicking opioid analgesia in cortical pain circuits. Nature 649, 938–947 (2026). https://doi.org/10.1038/s41586-025-09908-w
Sophie A. Rogers, Corinna S. Oswell, Lindsay L. Ejoh, Gregory Corder. Differential modulation of aversive signaling by expectation across the cingulate cortex. bioRxiv 2026.01.05.697709; doi: https://doi.org/10.64898/2026.01.05.697709
Rogers, S.A., Heller, E.A. & Corder, G. Psilocybin-enhanced fear extinction linked to bidirectional modulation of cortical ensembles. Nat Neurosci 28, 1311–1326 (2025). https://doi-org.proxy.library.upenn.edu/10.1038/s41593-025-01964-9
Awards
Next Generation Fellow
Lurie Austism Institute, UPenn. 2026
F31 NRSA
NIH NINDS, 2025
Best Research Talk
Philadelphia Chapter of SfN, 2024
Honorable Mention
NSF GRFP, 2020
Summer Research Fellowship
Irene and Eric Simon BRF, 2018
Neuroscience Honors Fellowship
University of Chicago, 2019
Jeff Metcalf Fellowship
University of Chicago, 2017
First Awards
NYC Science and Engineering Fair, 2015